iOS Pick: PiPifier
Jason Snell's pick of the week on MacBreak Weekly 563 is PiPifier for iOS. This is an action extension for Safari that allows you to play any HTML5 web video in Picture-in-Picture mode. This extension will even run on sites that hide the native video controls.
Once PiPifier is installed, all you need to do is open Safari, then open the Share Menu, choose "More," and enable "Run PiPifier." Then you'll find Pipifier in the Safari Share Menu, and you can turn on Picture-in-Picture from there while playing a video.